Publications

Key publications:

Groppa, S. and S. Meuth (2021). “Translational Methods for Multiple Sclerosis Research.” Springer Neuromethods Book. Link: https://www.springer.com/gp/book/9781071612125

Fleischer, V., G. Gonzalez-Escamilla, D. Ciolac, P. Albrecht, P. Kury, J. Gruchot, M. Dietrich, C. Hecker, T. Muntefering, S. Bock, M. Oshaghi, A. Radetz, M. Cerina, J. Kramer, L. Wachsmuth, C. Faber, H. Lassmann, T. Ruck, S. G. Meuth, M. Muthuraman and S. Groppa (2021). “Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans.” Proc Natl Acad Sci U S A 118(36). Link: https://doi.org/10.1073/pnas.2025000118

Muthuraman M, Bange M, Koirala N, Ciolac D, Pintea B, Glaser M, Tinkhauser G, Brown P, Deuschl G, Groppa S (2020). Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in cortico-subcortical networks in Parkinson’s disease patients Brain; Link: https://doi.org/10.1093/brain/awaa297

Gonzalez-Escamilla, G., M. Muthuraman, D. Ciolac, V. A. Coenen, A. Schnitzler and S. Groppa (2020). “Neuroimaging and electrophysiology meet invasive neurostimulation for causal interrogations and modulations of brain states.” Neuroimage 220: 117144. Link: https://doi.org/10.1016/j.neuroimage.2020.117144

Gonzalez-Escamilla G, Muthuraman M, Reich MM, Koirala N, Riedel C, Glaser M, …, Groppa S (2019). Cortical Network Fingerprints Predict Deep Brain Stimulation Outcome in Dystonia. Movement Disorders; Link: https://doi.org/10.1002/mds.27808

Krämer J, Cerina M, Zipp F, Wolfgang Brueck, Groppa S, Meuth S (2019). Imaging in mice and men: pathophysiological insights into multiple sclerosis from conventional and advanced MRI techniques. Progress in Neurobiology; Link: https://doi.org/10.1016/j.pneurobio.2019.101663

Muthuraman, M., J. Raethjen, N. Koirala, A. R. Anwar, K. G. Mideksa, R. Elble, S. Groppa* and G. Deuschl* (2018). “Cerebello-cortical network fingerprints differ between essential, Parkinson’s and mimicked tremors.” Brain Link: http://dx.doi.org/10.1093/brain/awy098

Groppa, S., J. Herzog, D. Falk, C. Riedel, G. Deuschl and J. Volkmann (2014). “Physiological and anatomical decomposition of subthalamic neurostimulation effects in essential tremor.” Brain 137(Pt 1): 109-121. Link: http://www.ncbi.nlm.nih.gov/pubmed/24277721

Sorted by year:

2021

Torres Diaz, C. V., G. González-Escamilla, D. Ciolac, M. Navas García, P. Pulido Rivas, R. G. Sola, A. Barbosa, J. Pastor, L. Vega-Zelaya and S. Groppa (2021). “Network Substrates of Centromedian Nucleus Deep Brain Stimulation in Generalized Pharmacoresistant Epilepsy.” Neurotherapeutics. Link: https://doi.org/10.1007/s13311-021-01057-y

Ding, H., S. Groppa and M. Muthuraman (2022). “Toward future adaptive deep brain stimulation for Parkinson’s disease: the novel biomarker – narrowband gamma oscillation.” Neural Regen Res 17(3): 557-558. Link: https://doi.org/10.4103/1673-5374.320984

Bange, M., S. Groppa and M. Muthuraman (2021). “Nonlinear irregularities in Parkinson’s disease tremor and essential tremor.” Clin Neurophysiol 132(9): 2255-2256. Link: https://doi.org/10.1016/j.clinph.2021.06.002

Scheunemann, A., K. Elsner, T. Germerott, S. Groppa, C. Hess, I. Miederer, A. Poplawski and J. Röhrich (2021). “Identification of Potential Distinguishing Markers for the Use of Cannabis-Based Medicines or Street Cannabis in Serum Samples.” Metabolites 11(5). Link: https://doi.org/10.3390/metabo11050316

Schnitzler, A., P. Mir, M. A. Brodsky, L. Verhagen, S. Groppa, R. Alvarez, A. Evans, M. Blazquez, S. Nagel, J. G. Pilitsis, M. Pötter-Nerger, W. Tse, L. Almeida, N. Tomycz, J. Jimenez-Shahed, W. Libionka, F. Carrillo, C. J. Hartmann, S. J. Groiss, M. Glaser, F. Defresne, E. Karst, B. Cheeran and J. Vesper (2021). “Directional Deep Brain Stimulation for Parkinson’s Disease: Results of an International Crossover Study With Randomized, Double-Blind Primary Endpoint.” Neuromodulation. Link: https://doi.org/10.1111/ner.13407

Vedam-Mai, V., K. Deisseroth, J. Giordano, G. Lazaro-Munoz, W. Chiong, N. Suthana, J. P. Langevin, J. Gill, W. Goodman, N. R. Provenza, C. H. Halpern, R. S. Shivacharan, T. N. Cunningham, S. A. Sheth, N. Pouratian, K. W. Scangos, H. S. Mayberg, A. Horn, K. A. Johnson, C. R. Butson, R. Gilron, C. de Hemptinne, R. Wilt, M. Yaroshinsky, S. Little, P. Starr, G. Worrell, P. Shirvalkar, E. Chang, J. Volkmann, M. Muthuraman, S. Groppa, A. A. Kühn, L. Li, M. Johnson, K. J. Otto, R. Raike, S. Goetz, C. Wu, P. Silburn, B. Cheeran, Y. J. Pathak, M. Malekmohammadi, A. Gunduz, J. K. Wong, S. Cernera, A. Wagle Shukla, A. Ramirez-Zamora, W. Deeb, A. Patterson, K. D. Foote and M. S. Okun (2021). “Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.” Front Hum Neurosci 15: 644593. Link: https://doi.org/10.3389/fnhum.2021.644593

Gonzalez-Escamilla, G. and S. Groppa (2021). “7 Tesla MRI will soon be helpful to guide clinical practice in multiple sclerosis centres – No.” Mult Scler 27(3): 362-363. Link: https://doi.org/10.1177/1352458520969662

Bahr, K., V. Geisler, T. Huppertz, S. Groppa, C. Matthias, H. Gouveris and M. Muthuraman (2021). “Intensity of Respiratory Cortical Arousals Is a Distinct Pathophysiologic Feature and Is Associated with Disease Severity in Obstructive Sleep Apnea Patients.” Brain Sci 11(3). Link: https://doi.org/10.3390/brainsci11030282

Khastkhodaei, Z., M. Muthuraman, J. W. Yang, S. Groppa and H. J. Luhmann (2021). “Functional and directed connectivity of the cortico-limbic network in mice in vivo.” Brain Struct Funct 226(3): 685-700. Link: https://doi.org/10.1007/s00429-020-02202-7

Michels, L., N. Koirala, S. Groppa, R. Luechinger, A. R. Gantenbein, P. S. Sandor, S. Kollias, F. Riederer and M. Muthuraman (2021). “Structural brain network characteristics in patients with episodic and chronic migraine.” J Headache Pain 22(1): 8. Link: https://doi.org/10.1186/s10194-021-01216-8

Seitz, C. B., F. Steffen, M. Muthuraman, T. Uphaus, J. Krämer, S. G. Meuth, P. Albrecht, S. Groppa, F. Zipp, S. Bittner and V. Fleischer (2021). “Serum neurofilament levels reflect outer retinal layer changes in multiple sclerosis.” Ther Adv Neurol Disord 14: 17562864211003478. Link: https://doi.org/10.1177/17562864211003478

Litvak, V., E. Florin, G. Tamás, S. Groppa and M. Muthuraman (2021). “EEG and MEG primers for tracking DBS network effects.” Neuroimage 224: 117447. Link: https://doi.org/10.1016/j.neuroimage.2020.117447

Bellmann-Strobl, J., F. Paul, J. Wuerfel, J. … S. Groppa, K. D. Wernecke and F. Zipp (2021). “Epigallocatechin Gallate in Relapsing-Remitting Multiple Sclerosis: A Randomized, Placebo-Controlled Trial.” Neurol Neuroimmunol Neuroinflamm 8(3). Link: https://doi.org/10.1212/nxi.0000000000000981

Ostkamp, P., A. Salmen, B. Pignolet, …, Groppa, K. Loser, H. Wiendl and N. Schwab (2021). “Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity.” Proc Natl Acad Sci U S A 118(1). Link: https://doi.org/10.1073/pnas.2018457118

2020

Porta, M., D. Servello, E. Zekaj, G. Gonzalez-Escamilla and S. Groppa (2020). “Pre-dopa Deep Brain Stimulation: Is Early Deep Brain Stimulation Able to Modify the Natural Course of Parkinson’s Disease?” Front Neurosci 14: 492. Link: https://doi.org/10.3389/fnins.2020.00492

Wiest, C., G. Tinkhauser, A. Pogosyan, M. Bange, M. Muthuraman, S. Groppa, F. Baig, A. Mostofi, E. A. Pereira, H. Tan, P. Brown and F. Torrecillos (2020). “Local field potential activity dynamics in response to deep brain stimulation of the subthalamic nucleus in Parkinson’s disease.” Neurobiol Dis: 105019. Link: https://doi.org/10.1016/j.nbd.2020.105019

Eggers, C., I. Wellach, S. Groppa, M. Strothjohann and J. Klucken (2020). “[Care of patients with Parkinson’s disease in Germany: status quo and perspectives as reflected in the digital transition].” Nervenarzt: 1-8. Link: https://doi.org/10.1007/s00115-020-01027-3

Koirala, N., L. Serrano, S. Paschen, D. Falk, A. R. Anwar, P. Kuravi, G. Deuschl, S. Groppa and M. Muthuraman (2020). “Mapping of subthalamic nucleus using microelectrode recordings during deep brain stimulation.” Sci Rep 10(1): 19241. Link: https://doi.org/10.1038/s41598-020-74196-5

Tamás, G., M. Fabbri, C. Falup-Pecurariu, T. …, S. Groppa, …, J. J. Ferreira (2020). “Lack of Accredited Clinical Training in Movement Disorders in Europe, Egypt, and Tunisia.” J Parkinsons Dis. Link: https://doi.org/10.3233/jpd-202000

Balestrini, S., M. A. Mikati, R. A. Garcia-Roves, …, S. Groppa, … Sisodiya (2020). “Cardiac phenotype in ATP1A3-related syndromes: A multicentre cohort study.” Neurology. Link: https://doi.org/10.1212/wnl.0000000000010794

Bittner, S., F. Steffen, T. Uphaus, M. Muthuraman, …, S. Groppa, …, F. Zipp (2020). “Clinical implications of serum neurofilament in newly diagnosed MS patients: A longitudinal multicentre cohort study.” EBioMedicine 56: 102807. Link: https://doi.org/10.1016/j.ebiom.2020.102807

Cerina, M., M. Muthuraman, M. Gallus, N. Koirala, A. Dik, L. Wachsmuth, P. Hundehege, P. Schiffler, J. G. Tenberge, V. Fleischer, G. Gonzalez-Escamilla, V. Narayanan, J. Krämer, C. Faber, T. Budde, S. Groppa and S. G. Meuth (2020). “Myelination- and immune-mediated MR-based brain network correlates.” J Neuroinflammation 17(1): 186. Link: https://doi.org/10.1186/s12974-020-01827-z

Gouveris, H., K. Bahr, E. Schmitt, A. Abriani, T. Boekstegers, S. Fassnacht, T. Huppertz, S. Groppa and M. Muthuraman (2020). “Corticoperipheral neuromuscular disconnection in obstructive sleep apnoea.” Brain Commun 2(1): fcaa056. Link: https://doi.org/10.1093/braincomms/fcaa056

Wang, Q., H. Akram, M. Muthuraman, G. Gonzalez-Escamilla, S. A. Sheth, S. Oxenford, F. C. Yeh, S. Groppa, N. Vanegas-Arroyave, L. Zrinzo, N. Li, A. Kühn and A. Horn (2020). “Normative vs. patient-specific brain connectivity in Deep Brain Stimulation.” Neuroimage: 117307. Link: https://doi.org/10.1016/j.neuroimage.2020.117307

Gonzalez-Escamilla, G., D. Ciolac, S. De Santis, A. Radetz, V. Fleischer, A. Droby, A. Roebroeck, S. G. Meuth, M. Muthuraman and S. Groppa (2020). “Gray matter network reorganization in multiple sclerosis from 7-Tesla and 3-Tesla MRI data.” Ann Clin Transl Neurol 7(4): 543-553. Link: https://doi.org/10.1002/acn3.51029

Gonzalez-Escamilla, G., I. Miederer, M. J. Grothe, M. Schreckenberger, M. Muthuraman and S. Groppa (2020). “Metabolic and amyloid PET network reorganization in Alzheimer’s disease: differential patterns and partial volume effects.” Brain Imaging Behav. Link: https://doi.org/10.1007/s11682-019-00247-9

Heitmann, H., B. Haller, L. … S. Groppa, F. Luessi, …, B. Hemmer and M. Ploner (2020). “Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study.” Pain 161(4): 787-796. Link: https://doi.org/10.1097/j.pain.0000000000001767

Abrahamyan, S., B. Eberspächer, M. M. Hoshi, …, S. Groppa, …, K. Ruprecht (2020). “Complete Epstein-Barr virus seropositivity in a large cohort of patients with early multiple sclerosis.” J Neurol Neurosurg Psychiatry 91(7): 681-686. Link: https://doi.org/10.1136/jnnp-2020-322941

Hossen, A., G. Deuschl, S. Groppa, U. Heute and M. Muthuraman (2020). “Discrimination of physiological tremor from pathological tremor using accelerometer and surface EMG signals.” Technol Health Care. Link: https://doi.org/10.3233/thc-191947

Muthuraman, M., V. Fleischer, J. Kroth, D. Ciolac, A. Radetz, N. Koirala, G. Gonzalez-Escamilla, H. Wiendl, S. G. Meuth, F. Zipp and S. Groppa (2020). “Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS.” Neurol Neuroimmunol Neuroinflamm 7(3). Link: https://doi.org/10.1212/nxi.0000000000000681

Fleischer, V., M. Muthuraman, A. R. Anwar, G. Gonzalez-Escamilla, A. Radetz, R. M. Gracien, S. Bittner, F. Luessi, S. G. Meuth, F. Zipp and S. Groppa (2020). “Continuous reorganization of cortical information flow in multiple sclerosis: A longitudinal fMRI effective connectivity study.” Sci Rep 10(1): 806. Link: https://doi.org/10.1038/s41598-020-57895-x

Muthuraman, M., M. Bange and S. Groppa (2020). “Advanced technologies for detecting tremor in Parkinson’s disease.” Clin Neurophysiol 131(1): 241-242. Link: https://doi.org/10.1016/j.clinph.2019.11.006

Radetz, A., V. Fleischer and S. Groppa (2020). “Dissecting task-specific plasticity capacity in patients with multiple sclerosis with transcranial magnetic stimulation.” Clin Neurophysiol 131(2): 472-473. Link: https://doi.org/10.1016/j.clinph.2019.11.027

Tinkhauser, G., F. Torrecillos, A. Pogosyan, A. Mostofi, M. Bange, P. Fischer, H. Tan, H. Hasegawa, M. Glaser, M. Muthuraman, S. Groppa, K. Ashkan, E. A. Pereira and P. Brown (2020). “The cumulative effect of transient synchrony states on motor performance in Parkinson’s disease.” J Neurosci. Link: https://doi.org/10.1523/jneurosci.1975-19.2019

2019

Radetz, A., N. Koirala, J. Krämer, A. Johnen, V. Fleischer, G. Gonzalez-Escamilla, M. Cerina, M. Muthuraman, S. G. Meuth and S. Groppa (2019). “Gray matter integrity predicts white matter network reorganization in multiple sclerosis.” Human Brain Mapping. Link: https://doi.org/10.1002/hbm.24849

Ciolac, D., F. Luessi, G. Gonzalez-Escamilla, N. Koirala, C. Riedel, V. Fleischer, S. Bittner, J. Kramer, S. G. Meuth, M. Muthuraman and S. Groppa (2019). “Selective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis.” Front Immunol 10: 1779. Link: https://doi.org/10.3389/fimmu.2019.01779

Engel, S., M. Friedrich, M. Muthuraman, F. Steffen, A. Poplawski, S. Groppa, S. Bittner, F. Zipp and F. Luessi (2019). “Intrathecal B-cell accumulation and axonal damage distinguish MRI-based benign from aggressive onset in MS.” Neurol Neuroimmunol Neuroinflamm 6(5). Link: https://doi.org/10.1212/nxi.0000000000000595

Koirala, N., A. R. Anwar, D. Ciolac, M. Glaser, B. Pintea, G. Deuschl, M. Muthuraman and S. Groppa (2019). “Alterations in White Matter Network and Microstructural Integrity Differentiate Parkinson’s Disease Patients and Healthy Subjects.” Front Aging Neurosci 11: 191. Link: https://doi.org/10.3389/fnagi.2019.00191

Chirumamilla, V. C., C. Dresel, N. Koirala, G. Gonzalez-Escamilla, G. Deuschl, K. E. Zeuner, M. Muthuraman and S. Groppa (2019). “Structural brain network fingerprints of focal dystonia.” Ther Adv Neurol Disord 12: 1756286419880664. Link: https://doi.org/10.1177/1756286419880664

Muthuraman, M., V. Moliadze, L. Boecher, J. Siemann, C. M. Freitag, S. Groppa and M. Siniatchkin (2019). “Multimodal alterations of directed connectivity profiles in patients with attention-deficit/hyperactivity disorders.” Sci Rep 9(1): 20028. Link: https://doi.org/10.1038/s41598-019-56398-8

Pflug, A., F. Gompf, M. Muthuraman, S. Groppa and C. A. Kell (2019). “Differential contributions of the two human cerebral hemispheres to action timing.” Elife 8. Link: https://doi.org/10.7554/eLife.48404

Gonzalez-Escamilla G, Muthuraman M, Reich MM, Koirala N, Riedel C, Glaser M, et al. Cortical Network Fingerprints Predict Deep Brain Stimulation Outcome in Dystonia. Movement Disorders. 2019; Link: https://doi.org/10.1002/mds.27808

Krämer J, Cerina M, Zipp F, Wolfgang Brueck, Groppa S, Meuth S. Imaging in mice and men: pathophysiological insights into multiple sclerosis from conventional and advanced MRI techniques. Progress in Neurobiology. 2019, Link: https://doi.org/10.1016/j.pneurobio.2019.101663

De Santis, S., M. Bastiani, A. Droby, P. Kolber, F. Zipp, E. Pracht, T. Stoecker, S. Groppa and A. Roebroeck (2019). “Characterizing microstructural tissue properties in multiple sclerosis with diffusion MRI at 7 T and 3 T: the impact of the experimental design.” Neuroscience 403: 17-26. Link: https://www.sciencedirect.com/science/article/pii/S0306452218302483

Chirumamilla, V. C., G. Gonzalez-Escamilla, N. Koirala, T. Bonertz, S. v. Grothus, M. Muthuraman and S. Groppa (2019). “Cortical excitability dynamics during fear processing.” Frontiers in Neuroscience 13: 568. Link: https://www.frontiersin.org/articles/10.3389/fnins.2019.00568/

Fleischer, V., N. Koirala, A. Droby, R. M. Gracien, R. Deichmann, U. Ziemann, S. G. Meuth, M. Muthuraman, F. Zipp and S. Groppa (2019). “Longitudinal cortical network reorganization in early relapsing-remitting multiple sclerosis.” Ther Adv Neurol Disord 12: 1756286419838673. Link: https://doi.org/10.1177/1756286419838673

Grahl, S., V. Pongratz, P. Schmidt, C. Engl, M. Bussas, A. Radetz, G. Gonzalez-Escamilla, S. Groppa, F. Zipp, C. Lukas, J. Kirschke, C. Zimmer, M. Hoshi, A. Berthele, B. Hemmer and M. Muhlau (2019). “Evidence for a white matter lesion size threshold to support the diagnosis of relapsing remitting multiple sclerosis.” Mult Scler Relat Disord 29: 124-129. Link: https://doi.org/10.1016/j.msard.2019.01.042

Johnen, A., P. C. Burkner, N. C. Landmeyer, B. Ambrosius, P. Calabrese, J. Motte, N. Hessler, G. Antony, I. R. Konig, L. Klotz, M. M. Hoshi, L. Aly, S. Groppa, F. Luessi, F. Paul, B. Tackenberg, F. T. Bergh, T. Kumpfel, H. Tumani, M. Stangel, F. Weber, A. Bayas, B. Wildemann, C. Heesen, U. K. Zettl, F. Zipp, B. Hemmer, S. G. Meuth, R. Gold, H. Wiendl and A. Salmen (2019). “Can we predict cognitive decline after initial diagnosis of multiple sclerosis? Results from the German National early MS cohort (KKNMS).” J Neurol 266(2): 386-397. Link: https://doi.org/10.1007/s00415-018-9142-y

McMackin, R., M. Muthuraman, S. Groppa, C. Babiloni, J. P. Taylor, M. C. Kiernan, B. Nasseroleslami and O. Hardiman (2019). “Measuring network disruption in neurodegenerative diseases: New approaches using signal analysis.” J Neurol Neurosurg Psychiatry. Link: https://doi.org/10.1136/jnnp-2018-319581

Schmidt, P., V. Pongratz, P. Kuster, D. Meier, J. Wuerfel, C. Lukas, B. Bellenberg, F. Zipp, S. Groppa, P. G. Samann, F. Weber, C. Gaser, T. Franke, M. Bussas, J. Kirschke, C. Zimmer, B. Hemmer and M. Muhlau (2019). “Automated segmentation of changes in FLAIR-hyperintense white matter lesions in multiple sclerosis on serial magnetic resonance imaging.” Neuroimage Clin 23: 101849. Link: https://doi.org/10.1016/j.nicl.2019.101849

2018

Gonzalez-Escamilla, G., V. C. Chirumamilla, B. Meyer, T. Bonertz, S. von Grotthus, J. Vogt, A. Stroh, J.-P. Horstmann, O. Tüscher, R. Kalisch, M. Muthuraman and S. Groppa (2018). “Excitability regulation in the dorsomedial prefrontal cortex during sustained instructed fear responses: a TMS-EEG study.” Scientific Reports 8(1): 14506. Link: https://doi.org/10.1038/s41598-018-32781-9

Winter, Y., N. Daneshkhah, N. Galland, I. Kotulla, A. Kruger and S. Groppa (2018). “Health-related quality of life in patients with poststroke epilepsy.” Epilepsy Behav 80: 303-306. Link: https://doi.org/10.101/j.yebeh.2017.12.037

Tamas, G., V. C. Chirumamilla, A. R. Anwar, J. Raethjen, G. Deuschl, S. Groppa and M. Muthuraman (2018). “Primary Sensorimotor Cortex Drives the Common Cortical Network for Gamma Synchronization in Voluntary Hand Movements.” Front Hum Neurosci 12: 130. Link: https://doi.org/10.3389/fnhum.2018.00130

Siller, N., J. Kuhle, M. Muthuraman, C. Barro, T. Uphaus, S. Groppa, L. Kappos, F. Zipp and S. Bittner (2018). “Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis.” Mult Scler: 1352458518765666. Link: https://doi.org/10.1177/1352458518765666

Seitz, C. B., A. Droby, L. Zaubitzer, J. Kramer, M. Paradis, L. Klotz, H. Wiendl, S. Groppa, S. G. Meuth, F. Zipp and V. Fleischer (2018). “Discriminative power of intra-retinal layers in early multiple sclerosis using 3D OCT imaging.” J Neurol 265(10): 2284-2294. Link: https://doi.org/10.1007/s00415-018-8988-3

Muthuraman, M., A. Schnitzler and S. Groppa (2018). “[Pathophysiology of tremor].” Nervenarzt 89(4): 408-415. Link: https://doi.org/10.1007/s00115-018-0490-8

Muthuraman, M., J. Raethjen, N. Koirala, A. R. Anwar, K. G. Mideksa, R. Elble, S. Groppa and G. Deuschl (2018). “Cerebello-cortical network fingerprints differ between essential, Parkinson’s and mimicked tremors.” Brain 141(6): 1770-1781. Link: https://doi.org/10.1093/brain/awy098

Muthuraman, M., N. Koirala, D. Ciolac, B. Pintea, M. Glaser, S. Groppa, G. Tamas and S. Groppa (2018). “Deep Brain Stimulation and L-DOPA Therapy: Concepts of Action and Clinical Applications in Parkinson’s Disease.” Front Neurol 9: 711. Link: https://doi.org/10.3389/fneur.2018.00711

Graetz, C., S. Groppa, F. Zipp and N. Siller (2018). “Preservation of neuronal function as measured by clinical and MRI endpoints in relapsing-remitting multiple sclerosis: how effective are current treatment strategies?” Expert Rev Neurother 18(3): 203-219. Link: https://doi.org/10.1080/14737175.2018.1438190

Allert, N., B. Cheeran, G. Deuschl, M. T. Barbe, I. Csoti, M. Ebke, M. Glaser, J. S. Kang, S. Kelm, P. Krack, J. Kroth, U. Jobst, M. Leisse, A. Oliviero, P. N. Nolte, J. Quick-Weller, M. Strothjohann, G. Tamas, M. Werner, M. Muthuraman, J. Volkmann, A. Fasano and S. Groppa (2018). “Postoperative rehabilitation after deep brain stimulation surgery for movement disorders.” Clin Neurophysiol 129(3): 592-601. Link: https://doi.org/10.1016/j.clinph.2017.12.035

2017

Muthuraman, M., G. Deuschl, N. Koirala, C. Riedel, J. Volkmann and S. Groppa (2017). “Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex.” Sci Rep 7: 43571. Link: https://doi.org/10.1038/srep43571

Kroth, J., D. Ciolac, V. Fleischer, N. Koirala, J. Kramer, M. Muthuraman, F. Luessi, S. Bittner, G. Gonzalez-Escamilla, F. Zipp, S. G. Meuth and S. Groppa (2017). “Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis.” Mult Scler: 1352458517748474. Link: https://doi.org/10.1177/1352458517748474

Kolber, P., A. Droby, A. Roebroeck, R. Goebel, V. Fleischer, S. Groppa and F. Zipp (2017). “A “kissing lesion”: In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis.” Mult Scler 23(8): 1167-1169. Link: https://doi.org/10.1177/1352458516683267

Koirala, N., V. Fleischer, M. Glaser, K. E. Zeuner, G. Deuschl, J. Volkmann, M. Muthuraman and S. Groppa (2017). “Frontal Lobe Connectivity and Network Community Characteristics are Associated with the Outcome of Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson’s Disease.” Brain Topography: 1-11. Link:

Gracien, R. M., S. C. Reitz, M. Wagner, C. Mayer, S. Volz, S. M. Hof, V. Fleischer, A. Droby, H. Steinmetz, S. Groppa, E. Hattingen, J. C. Klein and R. Deichmann (2017). “Comparison of two quantitative proton density mapping methods in multiple sclerosis.” MAGMA 30(1): 75-83. Link: https://doi.org/10.1007/s10334-016-0585-9

Chiosa, V., S. A. Groppa, D. Ciolac, N. Koirala, L. Misina, Y. Winter, M. Moldovanu, M. Muthuraman and S. Groppa (2017). “Breakdown of Thalamo-Cortical Connectivity Precedes Spike Generation in Focal Epilepsies.” Brain Connect 7(5): 309-320. Link: https://doi.org/10.1089/brain.2017.0487

Fleischer, V., A. Radetz, D. Ciolac, M. Muthuraman, G. Gonzalez-Escamilla, F. Zipp and S. Groppa (2017). “Graph Theoretical Framework of Brain Networks in Multiple Sclerosis: A Review of Concepts.” Neuroscience. Link: https://doi.org/10.1016/j.neuroscience.2017.10.033

Fleischer, V., A. Groger, N. Koirala, A. Droby, M. Muthuraman, P. Kolber, E. Reuter, S. G. Meuth, F. Zipp and S. Groppa (2017). “Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis.” Mult Scler 23(3): 432-441. Link: https://doi.org/10.1177/1352458516651503

Chirumamilla, V. C., N. Koirala and S. Groppa (2017). “Combining transcranial magnetic stimulation and subdural electrodes for pain modulation.” Clin Neurophysiol 128(6): 1041-1042. Link: https://doi.org/10.1016/j.clinph.2017.03.003

Gracien, R. M., S. C. Reitz, S. M. Hof, V. Fleischer, A. Droby, M. Wahl, H. Steinmetz, S. Groppa, R. Deichmann and J. C. Klein (2017). “Longitudinal quantitative MRI assessment of cortical damage in multiple sclerosis: A pilot study.” J Magn Reson Imaging 46(5): 1485-1490. Link: https://doi.org/10.1002/jmri.25685

Vergotte, G., K. Torre, V. C. Chirumamilla, A. R. Anwar, S. Groppa, S. Perrey and M. Muthuraman (2017). “Dynamics of the human brain network revealed by time-frequency effective connectivity in fNIRS.” Biomed Opt Express 8(11): 5326-5341. Link: https://doi.org/10.1364/BOE.8.005326

2016

Fleischer, V., R. Kolb, S. Groppa, F. Zipp, U. Klose and A. Groger (2016). “Metabolic Patterns in Chronic Multiple Sclerosis Lesions and Normal-appearing White Matter: Intraindividual Comparison by Using 2D MR Spectroscopic Imaging.” Radiology 281(2): 536-543. Link: https://doi.org/10.1148/radiol.2016151654

Fleischer, V., R. Kolb, U. Klose, S. Groppa, A. Zipp and A. Gröger (2016). “Intra-individual comparison of metabolic patterns in chronic multiple sclerosis lesions and normal appearing white matter using 2D MRSI.” Radiology In press. Link:

Gracien, R. M., A. Jurcoane, M. Wagner, S. C. Reitz, C. Mayer, S. Volz, S. M. Hof, V. Fleischer, A. Droby, H. Steinmetz, S. Groppa, E. Hattingen, R. Deichmann and J. C. Klein (2016). “Multimodal quantitative MRI assessment of cortical damage in relapsing-remitting multiple sclerosis.” J Magn Reson Imaging 44(6): 1600-1607. Link: https://doi.org/10.1002/jmri.25297

Groppa, S. (2016). “Multifocal TMS for temporo-spatial description of cortico-cortical connectivity patterns.” Clin Neurophysiol 127(2): 1005-1006. Link: https://doi.org/10.1016/j.clinph.2015.07.012

Keshavan, A., F. Paul, M. K. Beyer, A. H. Zhu, N. Papinutto, R. T. Shinohara, W. Stern, M. Amann, R. Bakshi, A. Bischof, A. Carriero, M. Comabella, J. C. Crane, S. D’Alfonso, P. Demaerel, B. Dubois, M. Filippi, V. Fleischer, B. Fontaine, L. Gaetano, A. Goris, C. Graetz, A. Groger, S. Groppa, D. A. Hafler, H. F. Harbo, B. Hemmer, K. Jordan, L. Kappos, G. Kirkish, S. Llufriu, S. Magon, F. Martinelli-Boneschi, J. L. McCauley, X. Montalban, M. Muhlau, D. Pelletier, P. M. Pattany, M. Pericak-Vance, I. Cournu-Rebeix, M. A. Rocca, A. Rovira, R. Schlaeger, A. Saiz, T. Sprenger, A. Stecco, B. M. J. Uitdehaag, P. Villoslada, M. P. Wattjes, H. Weiner, J. Wuerfel, C. Zimmer, F. Zipp, A. P. O. International Multiple Sclerosis Genetics Consortium. Electronic address, S. L. Hauser, J. R. Oksenberg and R. G. Henry (2016). “Power estimation for non-standardized multisite studies.” Neuroimage 134: 281-294. Link: https://doi.org/10.1016/j.neuroimage.2016.03.051

Luessi, F., V. Fleischer, M. Friedrich, A. Rezk, U. Buehler, E. Witsch, T. Uphaus, S. Bittner, S. Groppa and A. Bar-Or (2016). Treatment response to dimethyl fumarate is characterized by CD8+ T cell reduction in multiple sclerosis. Multiple Sclerosis Journal, SAGE PUBLICATIONS LTD 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND.

Muthuraman, M., C. V. Chirumamilla and S. Groppa (2016). “Establishing standards for neuronavigated TMS in research and clinical studies.” Clin Neurophysiol 127(8): 2890-2891. Link: https://doi.org/10.1016/j.clinph.2016.05.009

Muthuraman, M., V. Fleischer, P. Kolber, F. Luessi, F. Zipp and S. Groppa (2016). “Structural Brain Network Characteristics Can Differentiate CIS from Early RRMS.” Frontiers in Neuroscience 10. Link: https://doi.org/10.3389/Fnins.7016.00014

Muthuraman, M., S. Groppa and G. Deuschl (2016). “Cerebello-cortical networks in orthostatic tremor.” Brain 139(Pt 8): 2104-2106. Link: https://doi.org/10.1093/brain/aww164

Muthuraman, M., G. Hartwigsen and S. Groppa (2016). “(Non-) invasive mapping of cortical language areas.” Clin Neurophysiol 127(3): 1762-1763. Link: https://doi.org/10.1016/j.clinph.2015.12.006

Deppe, M., J. Kramer, J. G. Tenberge, J. Marinell, W. Schwindt, K. Deppe, S. Groppa, H. Wiendl and S. G. Meuth (2016). “Early silent microstructural degeneration and atrophy of the thalamocortical network in multiple sclerosis.” Hum Brain Mapp 37(5): 1866-1879. Link: https://doi.org/10.1002/hbm.23144

Alexandru, H., M. Muthuraman, V. C. Chirumamilla, N. Koirala, B. Paktas, G. Deuschl, K. E. Zeuner and S. Groppa (2016). “Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy.” PLoS One 11(12): e0168652. Link: https://doi.org/10.1371/journal.pone.0168652

Anwar, A. R., M. Y. Hashmy, B. Imran, M. H. Riaz, S. M. Mehdi, M. Muthalib, S. Perrey, G. Deuschl, S. Groppa and M. Muthuraman (2016). “Complex network analysis of resting-state fMRI of the brain.” Conf Proc IEEE Eng Med Biol Soc 2016: 3598-3601. Link: https://doi.org/10.1109/EMBC.2016.7591506

Koirala, N., V. Fleischer, O. Granert, G. Deuschl, M. Muthuraman and S. Groppa (2016). Network effects and pathways in Deep brain stimulation in Parkinson’s disease. Engineering in Medicine and Biology Society (EMBC), 2016 IEEE 38th Annual International Conference of the, IEEE.

Droby, A., K. S. Yuen, M. Muthuraman, S. C. Reitz, V. Fleischer, J. Klein, R. M. Gracien, U. Ziemann, R. Deichmann, F. Zipp and S. Groppa (2016). “Changes in brain functional connectivity patterns are driven by an individual lesion in MS: a resting-state fMRI study.” Brain Imaging Behav 10(4): 1117-1126. Link: https://doi.org/10.1007/s11682-015-9476-3

Fleischer, V., S. Groppa and F. Zipp (2016). “Neue Wege in der Bildgebung der Multiplen Sklerose.” Neuro Aktuell 3344: 3-6. Link:

2015

Vogt, J., J. Yang, A. Mobascher, J. Cheng, J. Li, X. Liu, J. Baumgart, C. Thalman, S. Kirischuk, P. Unichenko, G. Horta, K. Radyushkin, A. Stroh, S. Richers, N. Sahragard, U. Distler, S. Tenzer, L. Qiao, K. Lieb, O. Tüscher, H. Binder, N. Ferreiros, I. Tegeder, A. Morris, S. Groppa, G. Winterer, H. Luhmann, J. Huai and R. Nitsch (2015). “Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP.” EMBO Molecular Medicine in press. Link:

Muthuraman, M., T. Anjum, A. Droby, V. Fleischer, S. Reitz, K. Mideksa, G. Schmidt, F. Zipp and S. Groppa (2015). Testing different ICA algorithms and connectivity analyses on MS patients. Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE, IEEE.

Hanganu, A., S. A. Groppa, G. Deuschl, H. Siebner, F. Moeller, M. Siniatchkin, U. Stephani and S. Groppa (2015). “Cortical Thickness Changes Associated with Photoparoxysmal Response.” Brain Topogr 28(5): 702-709. Link: https://doi.org/10.1007/s10548-014-0353-y

2014 and older

Groppa, S. (2014). “U-shape effects of lithium on motor cortex excitability or possible mechanisms of an “old” first line therapy.” Clin Neurophysiol 125(11): 2144-2145. Link: https://doi.org/10.1016/j.clinph.2014.04.006

Muthuraman, M., H. Hellriegel, S. Groppa, G. Deuschl and J. Raethjen (2013). The cortical and sub-cortical network of sensory evoked response in healthy subjects. Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE, IEEE.

Groppa, S., M. Muthuraman, B. Otto, G. Deuschl, H. R. Siebner and J. Raethjen (2013). “Subcortical substrates of TMS induced modulation of the cortico-cortical connectivity.” Brain Stimul 6(2): 138-146. Link: https://doi.org/10.1016/j.brs.2012.03.014

Groppa, S., O. Granert, B. Paktas, J. Munz, C. Riedel, G. Deuschl and J. Volkmann (2013). “Elucidating the systemic effects of deep brain stimulation in Parkinson’s disease with diffusion tensor imaging (DTI).” Klinische Neurophysiologie 43(01): 049. Link:

Muthuraman, M., S. Paschen, H. Hellriegel, S. Groppa, G. Deuschl and J. Raethjen (2012). Locating the STN-DBS electrodes and resolving their subsequent networks using coherent source analysis on EEG. Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE, IEEE.

Groppa, S., N. Werner-Petroll, A. Munchau, G. Deuschl, M. F. Rushworth and H. R. Siebner (2012). “A novel dual-site transcranial magnetic stimulation paradigm to probe fast facilitatory inputs from ipsilateral dorsal premotor cortex to primary motor cortex.” Neuroimage 62(1): 500-509. Link: https://doi.org/10.1016/j.neuroimage.2012.05.023

Groppa, S., B. H. Schlaak, A. Munchau, N. Werner-Petroll, J. Dunnweber, T. Baumer, B. F. van Nuenen and H. R. Siebner (2012). “The human dorsal premotor cortex facilitates the excitability of ipsilateral primary motor cortex via a short latency cortico-cortical route.” Hum Brain Mapp 33(2): 419-430. Link: https://doi.org/10.1002/hbm.21221

Groppa, S., A. Oliviero, A. Eisen, A. Quartarone, L. G. Cohen, V. Mall, A. Kaelin-Lang, T. Mima, S. Rossi, G. W. Thickbroom, P. M. Rossini, U. Ziemann, J. Valls-Sole and H. R. Siebner (2012). “A practical guide to diagnostic transcranial magnetic stimulation: report of an IFCN committee.” Clin Neurophysiol 123(5): 858-882. Link: https://doi.org/10.1016/j.clinph.2012.01.010

Groppa, S., F. Moeller, H. Siebner, S. Wolff, C. Riedel, G. Deuschl, U. Stephani and M. Siniatchkin (2012). “White matter microstructural changes of thalamocortical networks in photosensitivity and idiopathic generalized epilepsy.” Epilepsia 53(4): 668-676. Link: https://doi.org/10.1111/j.1528-1167.2012.03414.x

Groppa, S., O. Granert, B. Paktas, J. Munz, C. Riedel, G. Deuschl and J. Volkmann (2012). “Elucidating the systemic effects of deep brain stimulation in Parkinson’s disease with diffusion tensor imaging (DTI).” Klinische Neurophysiologie 43(01): V049. Link: https://doi.org/10.1055/s-0032-1301460

Depienne, C., D. Bouteiller, A. Meneret, S. Billot, S. Groppa, S. Klebe, F. Charbonnier-Beaupel, J. C. Corvol, J. P. Saraiva, N. Brueggemann, K. Bhatia, M. Cincotta, V. Brochard, C. Flamand-Roze, W. Carpentier, S. Meunier, Y. Marie, M. Gaussen, G. Stevanin, R. Wehrle, M. Vidailhet, C. Klein, I. Dusart, A. Brice and E. Roze (2012). “RAD51 haploinsufficiency causes congenital mirror movements in humans.” Am J Hum Genet 90(2): 301-307. Link: https://doi.org/10.1016/j.ajhg.2011.12.002

Granert, O., M. Peller, C. Gaser, S. Groppa, M. Hallett, A. Knutzen, G. Deuschl, K. E. Zeuner and H. R. Siebner (2011). “Manual activity shapes structure and function in contralateral human motor hand area.” Neuroimage 54(1): 32-41. Link: https://doi.org/10.1016/j.neuroimage.2010.08.013

Depienne, C., M. Cincotta, S. Billot, D. Bouteiller, S. Groppa, V. Brochard, C. Flamand, C. Hubsch, S. Meunier, F. Giovannelli, S. Klebe, J. C. Corvol, M. Vidailhet, A. Brice and E. Roze (2011). “A novel DCC mutation and genetic heterogeneity in congenital mirror movements.” Neurology 76(3): 260-264. Link: https://doi.org/10.1212/WNL.0b013e318207b1e0

Verleger, R., F. Moller, M. Kuniecki, K. Smigasiewicz, S. Groppa and H. R. Siebner (2010). “The left visual-field advantage in rapid visual presentation is amplified rather than reduced by posterior-parietal rTMS.” Exp Brain Res 203(2): 355-365. Link: https://doi.org/10.1007/s00221-010-2237-z

Groppa, S., M. Peller and H. R. Siebner (2010). “Funktionsdiagnostik der kortikomotorischen Bahnen mit der transkraniellen Magnetstimulation: eine Einführung.” Klinische Neurophysiologie 41(01): 12-22. Link: https://doi.org/10.1055/s-0029-1220905

Groppa, S., T. O. Bergmann, C. Siems, M. Molle, L. Marshall and H. R. Siebner (2010). “Slow-oscillatory transcranial direct current stimulation can induce bidirectional shifts in motor cortical excitability in awake humans.” Neuroscience 166(4): 1219-1225. Link: https://doi.org/10.1016/j.neuroscience.2010.01.019

Bergmann, T. O., S. Groppa, M. Seeger, M. Molle, L. Marshall and H. R. Siebner (2009). “Acute changes in motor cortical excitability during slow oscillatory and constant anodal transcranial direct current stimulation.” J Neurophysiol 102(4): 2303-2311. Link: https://doi.org/10.1152/jn.00437.2009

Siebner, H. R., T. O. Bergmann, S. Bestmann, M. Massimini, H. Johansen-Berg, H. Mochizuki, D. E. Bohning, E. D. Boorman, S. Groppa, C. Miniussi, A. Pascual-Leone, R. Huber, P. C. Taylor, R. J. Ilmoniemi, L. De Gennaro, A. P. Strafella, S. Kahkonen, S. Kloppel, G. B. Frisoni, M. S. George, M. Hallett, S. A. Brandt, M. F. Rushworth, U. Ziemann, J. C. Rothwell, N. Ward, L. G. Cohen, J. Baudewig, T. Paus, Y. Ugawa and P. M. Rossini (2009). “Consensus paper: combining transcranial stimulation with neuroimaging.” Brain Stimul 2(2): 58-80. Link: https://doi.org/10.1016/j.brs.2008.11.002

Smigasiewicz, K., R. Verleger, F. Moller, M. Kuniecki, S. Groppa and H. R. Siebner (2009). “Modulating the left-hemifield bias in rapid serial visual presentation by repetitive transcranial magnetic stimulation.” Psychophysiology 46: S119-S119. Link:

Potter-Nerger, M., S. Fischer, C. Mastroeni, S. Groppa, G. Deuschl, J. Volkmann, A. Quartarone, A. Munchau and H. R. Siebner (2009). “Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs.” J Neurophysiol 102(6): 3180-3190. Link: https://doi.org/10.1152/jn.91046.2008

Zeuner, K. E., M. Peller, A. Knutzen, S. Groppa, I. Holler, F. Kopper, J. Raethjen, D. Dressler, M. Hallett, G. Deuschl and H. R. Siebner (2009). “Slow pre-movement cortical potentials do not reflect individual response to therapy in writer’s cramp.” Clin Neurophysiol 120(6): 1213-1219. Link: https://doi.org/10.1016/j.clinph.2009.04.010

Groppa, S., H. R. Siebner, C. Kurth, U. Stephani and M. Siniatchkin (2008). “Abnormal response of motor cortex to photic stimulation in idiopathic generalized epilepsy.” Epilepsia 49(12): 2022-2029. Link: https://doi.org/10.1111/j.1528-1167.2008.01709.x

Groppa, S., N. Werner-Petroll, O. Granert, G. Hartwigsen and H. Siebner (2008). “Probing premotor-to-motor interactions in the left hemisphere during movement selection with highly focal TMS and DTI.” Aktuelle Neurologie 35(S 01): P607. Link: https://doi.org/10.1055/s-0028-1086861

Popa-Wagner, A., I. Badan, L. Walker, S. Groppa, N. Patrana and C. Kessler (2007). “Accelerated infarct development, cytogenesis and apoptosis following transient cerebral ischemia in aged rats.” Acta Neuropathol 113(3): 277-293. Link: https://doi.org/10.1007/s00401-006-0164-7

Siniatchkin, M., S. Groppa, B. Jerosch, H. Muhle, C. Kurth, A. J. Shepherd, H. Siebner and U. Stephani (2007). “Spreading photoparoxysmal EEG response is associated with an abnormal cortical excitability pattern.” Brain 130(Pt 1): 78-87. Link: https://doi.org/10.1093/brain/awl306

Siniatchkin, M., S. Groppa, H. Siebner and U. Stephani (2006). “A single dose of sulthiame induces a selective increase in resting motor threshold in human motor cortex: A transcranial magnetic stimulation study.” Epilepsy Res 72(1): 18-24. Link: https://doi.org/10.1016/j.eplepsyres.2006.07.001

Siniatchkin, M., S. Groppa, B. Jerosch, H. Muhle, U. Stephani and H. Siebner (2006). “Excitatory and inhibitory mechanisms of photosensitivity.” Klinische Neurophysiologie 37(01): A206. Link: https://doi.org/10.1055/s-2006-939289